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Lesogaberan, AZD3355

L00672

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CAS No.: 344413-67-8

Molecular Formula: C3H9FNO2P

Molecular Weight:: 141.08

Chemical Name: [(2R)-3-amino-2-fluoropropyl]phosphinic acid; (R)-(3-Amino-2-fluoropropyl) Phosphinic Acid

Lesogaberan (AZD3355) is a novel reflux inhibitor developed as an add-on treatment to proton pump inhibitors (PPIs) for symptom relief in patients with gastroesophageal reflux disease who have a partial response to PPI therapy.

Reference:

1.   Lesogaberan add-on therapy to PPIs significantly improved heartburn and regurgitation symptoms; however, the proportion of responders was small. G.E.Boeckxstaens et al.: Gut 2011;60:1182-1188 "A  novel reflux inhibitor lesogaberan (AZD3355) as add-on treatment in patients with GORD with persistent reflux symptoms despite proton pump inhibitor therapy: a randomised placebo-controlled trial." Fll text

2. Compared with placebo, lesogaberan significantly reduced TLESRs and acid reflux episodes and increased LES pressure. Boeckxstaens et al.: Alimentary Pharmacology & Therapeutics 2010, 31(11):1208-1217 "Effect of lesogaberan, a novel GABA(B)-receptor agonist, on transient lower oesophageal sphincter relaxations in male subjects." Full text

The product is only for R&D purpose,not for human use.We will not take any responsibility for illegal use.

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