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Avasimibe(CI-1011)


CAS No.: 166518-60-1 

Molecular Formula: C29H43NO4S

Molecular Weight (WM):501.72

Chemical Name: N-(2,6-Dipropan-2-ylphenoxy)sulfonyl-2-(2,4,6-tripropan-2-ylphenyl)acetamide

Synonyms: CI-1011

Avasimibe, an acyl-CoA:cholesterol acyltransferase inhibitor, has been previously shown to be a potent inducer of CYP3A4 and multiple drug resistance protein 1. Avasimibe is an inhibitor of acyl-CoA:cholesterol acyltransferase, the enzyme that catalyzes the intracellular esterification of cholesterol.

Reference:

1. F.J. Raal et al. / Atherosclerosis 171 (2003) 273–279 "Avasimibe, an ACAT inhibitor, enhances the lipid lowering effect of atorvastatin in subjects with homozygous familial hypercholesterolemia"  Full text

2. J.R. Burnett et al. / Biochimica et Biophysica Acta 1738 (2005) 10–18 "The ACAT inhibitor avasimibe increases the fractional clearance rate of postprandial triglyceride-rich lipoproteins in miniature pigs" Full text

The product is only for R&D purpose,not for human use.We will not take any responsibility for illegal use.

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