Antia Laboratories Inc.

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VX-745


CAS Number: 209410-46-8

Molecular Formula: C19H9Cl2F2N3OS

Molecular Weight: 436.26

Chemical Name: 5-(2,6-Dichlorophenyl)-2-[2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one

Appearance: Yellow solid

Purity: 99%+

VX-745 is a lead anti-inflammatory candidate, small-molecule inhibitor of mitogen-activated protein kinase (MAPK).VX-745 is potent against p38R (IC50=10 nM)  and blocks TNFR production in LPS-stimulated HWB in vitro (IC50=177 nM). (1)

Reference:

1.VX-745 is potent against p38R (IC50=10 nM)  and blocks TNFR production in LPS-stimulated HWB in vitro (IC50=177 nM).  Goldstein et al.: J. Med. Chem. 2010,53,2345-2353 Full text

2.VX-745 displays excellent enzyme activity and selectivity, has a favorable pharmacokinetic profile, and demonstrates good in vivo activity in models of inflammation. Duffy et al.: Med.Chem.Lett. 2011,2,758-763 Full text

The product is only for R&D purpose,not for human use.We will not take any responsibility for illegal use.

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