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Hypericin

H00167

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CAS Number.: 548-04-9

Molecular Formula: C30H16O8

Molecular Weight: 504.44

Synonyms: 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione

 

Hypericin was originally isolated from Hypericum perforatum L. (St. John's Wort). Can be additionally isolated via irradiation of oxypenicilliopsin produced by Penicilliopsis clavariaeformis. A potent and selective inhibitor of protein kinase C (PKC) and additionally reported to inhibit CKII, MAP Kinase, Insulin R, EGFR, PI-3 Kinase. Hypericin is also noted to possess antiviral activity and is of interest in HIV studies. Hypericin is of interest in studies investigating photodynamic treatment of tumors and has been reported to be cytotoxic to some tumor cell lines when Hypericin is photoactivated.

Reference:

1.Hypericin is a very promising tool in the photodynamic treatment of cancers. P. Agostinis et al.: The International Journal of Biochemistry & Cell Biology 34 (2002) 221–241 Full text

2.Hypericin, inhibits glutamate release in the rat cerebrocortical synaptosomes via a mitogen-activated protein kinase-dependent pathway.Y. Chang, S.-J. Wang et al.: European Journal of Pharmacology 634 (2010) 53–61 Full text

 

The product is only for R&D purpose,not for human use.We will not take any responsibility for illegal use.

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