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Cilengitide (EMD 121974)


CAS Number: 188968-51-6
Molecular Formula: C27H40N8O7
Molecular Weight: 588.66

CAS Number: 188968-51-6

Molecular Formula: C27H40N8O7

Molecular Weight: 588.66

Chemical Name: 2-[(2S,5R,8S,11S)-5-benzyl-11-{3-[(diaminomethylidene)amino]propyl}-7-methyl-3,6,9,12,15-pentaoxo-8-(propan-2-yl)-1,4,7,10,13-pentaazacyclopentadecan-2-yl]acetic acid

Reference:

1. Cilengitide is a radiosensitizer in proportion to the levels of target integrin expression. J. M. ALBERT et al.:Int. J. Radiation Oncology Biol. Phys.,65(5) 1536-1543,2006 Full text

2.Cilengitide Blocks αVβ3 Integrin-Mediated, Rgd-Dependent Activation of Latent TGF-β1 and Attenuates Fibrosis in TNBS-Induced Colitis and Human Muscle of Stricturing Crohn's Diseas. Robert S. Flynn et al.: Gastroenterology, 140, 5, Supplement 1,S-109,2011 Full text

3.Cilengitide inhibits proliferation and differentiation of human endothelial progenitor cells in vitro.S. Loges et al.: Biochemical and Biophysical Research Communications 357 (2007) 1016–1020 Full text

4.Cilengitide (EMD 121974) arrests the growth of a heavily pretreated highly vascularised head and neck tumour. J.-D. Raguse et al.: Oral Oncology (2004) 40 228–230

5.Cilengitide inhibits progression of experimental breast cancer bone metastases as imaged noninvasively using VCT, MRI and DCE-MRI in a longitudinal in vivo study. Bauerle et al.: Int. J. Cancer: 128, 2453-2462(2011) Full text

 

The product is only for R&D purpose,not for human use.We will not take any responsibility for illegal use.

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