Antia Laboratories Inc.

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Telotristat etiprate (LX1606, LX1032)

L00858

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CAS Number: 1137608-69-5

Molecular Formula: C27H26ClF3N6O3.C9H9NO3

Molecular Weight: 754.15

Chemical Name:

L-Phenylalanine, 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]- 2,2,2-  trifluoroethoxy]-4-pryrimidinyl]-, ethyl ester, compd. with N-benzoylglycine (1:1) 

ethyl 4-(2-amino-6-{(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2- trifluoroethoxy}pryrimidin-4-yl)-L-phenylalaninate N-benzoylglycinate (1:1)

LX1606 (LX 1606, LX-1606) is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Upon administration, LX1606 (LX 1606, LX-1606) is converted to its active metabolite LP-778902, which binds to and blocks the activity of TPH. This may result in a reduction in peripheral serotonin (5-HT) production and improvement of serotonin-mediated gastrointestinal effects such as severe diarrhea. TPH, the rate-limiting enzyme in serotonin biosynthesis, is overexpressed in carcinoid tumor cells. 

LX1606 (LX 1606, LX-1606) is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Upon administration, LX1606 (LX 1606, LX-1606) is converted to its active metabolite LP-778902, which binds to and blocks the activity of TPH. This may result in a reduction in peripheral serotonin (5-HT) production and improvement of serotonin-mediated gastrointestinal effects such as severe diarrhea. TPH, the rate-limiting enzyme in serotonin biosynthesis, is overexpressed in carcinoid tumor cells. 

 


The product is only for R&D purpose,not for human use.We will not take any responsibility for illegal use.

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