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CAS Number: 302-27-2

Molecular Formula: C34H47NO11

Molecular Weight: 645.7

Melting Point: 204 °C

Specific Rotation: +17.3°

Synonym: (1α,3α,6α,14α,15α,16β)-20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol 8-acetate 14-benzoate1

Aconitine is an alkaloid with a diterpenoid structure that occurs naturally in the roots of Aconitum napellus (Ranunculaceae), or the monkshood plant. Being the principal alkaloid in the A. napellus root, aconitine has been studied for its pharmacological properties.One mechanism of action is suppression of the inactivation of voltage-dependent Na+ channels via the binding to neurotoxin binding site 2 of the α-subunit of the channel protein.


1. The Merck Index, 12th ed., Entry# 120.

2. Martindale The Extra Pharmacopoeia, 31st ed.,Reynolds, J. E. F., ed., Royal Pharmaceutical Society (London, UK: 1996), p. 1668.

3. Ameri, A., The effects of Aconitum alkaloids on the central nervous system. Prog. Neurobiol., 56(2),211-235 (1998).

4. Wang, S. Y., and Wang, G. K., Voltage-gated sodium channels as primary targets of diverse lipid-soluble neurotoxins. Cell. Signal., 15(2),151-159 (2003).

5. Ameri, A., and Simmet, T., Interaction of the structurally related aconitum alkaloids, aconitine and 6-benzyolheteratisine, in the rat hippocampus. Eur. J. Pharmacol., 386(2-3), 187-194 (1999).

6. Kimura, I., et al., Expression of major histocompatibility complex in mouse peritoneal macrophages increasingly depends on plasma corticosterone levels: stimulation by aconitine. Biol. Pharm. Bull., 18(11), 1504-1508 (1995).

7. Ameri, A., et al., Bicuculline-induced epileptiform activity in rat hippocampal slices: suppression by Aconitum alkaloids. Planta Med., 63(3), 228-232 (1997).

8. Ohta, H., et al., Determination of Aconitum alkaloids in blood and urine samples. I. Highperformance liquid chromatographic separation, solid-phase extraction and mass spectrometric confirmation. J. Chromatogr. B Biomed. Sci.Appl., 691(2), 351-356 (1997).

9. Ohta, H., et al., Determination of Aconitum alkaloids in blood and urine samples. II. Capillary liquid chromatographic-frit fast atom bombardment mass spectrometric analysis. J. Chromatogr. B Biomed. Sci. Appl., 714(2), 215-221 (1998).

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