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Epothilone D


CAS Number: 189453-10-9

Mol. Formula: C27H41NO5S

Mol. Weight: 491.68

Synonyms:
(4S,7R,8S,9S,13Z,16S)-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]oxacyclohexadec-13-ene-2,6-dione; (-)-Desoxyepothilone B; (-)-Epothilone D; 12,13-Deoxyepothilone B; 12,13-Desoxyepothilone B; Desoxyepothilone B; Epo D; Epothilone D; KOS 862; NSC 703147; 

Aplications:
Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid 

References:
1.Bollag, D.M., et al.: Cancer. Res., 55, 2325 (1995)
2.Hardt, I.H., et al.: J. Nat. Prod., 64, 847 (2001)
3.Gerth, K., et al.: J. Antibiot., 55, 41, 45 (2002) 

The product is only for R&D purpose,not for human use.We will not take any responsibility for illegal use.

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